Microcarrier with 20 nanometre pores
Drug molecules can be loaded within the nanopores/mesopores of our carrier which leads to:
Surface anchoring – Drug molecules attach to internal pore surfaces in random orientations
Amorphous formation – Molecules continue to cluster into a random amorphous form within pores.
Amorphous form confined – The pore dimensions limit the growth of molecular cluster preventing the formation of the poorly soluble crystalline drug.
Therefore, the drug stays in the amorphous form which has better dissolution and bioavailability (absorption) in the body.